423.2K XNAS Volume
XNAS 18 Mar, 2025 5:30 PM (EDT)
| Client Name | Client Category | Action | Reported to Exchange | Quantity | Post Transaction Holding | Traded % | Avg. Price | Value | Security Type |
|---|---|---|---|---|---|---|---|---|---|
| Howard Horn | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 40.40 per share. | 06 Mar 2025 | 1,785 | 106,169 (0%) | 0% | 40.4 | 72,114 | Common Stock |
| Erik Harris | EVP & Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2025 | 30,246 | 30,246 | - | - | Stock Option (Right to Buy) | |
| Howard Horn | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2025 | 28,160 | 28,160 | - | - | Stock Option (Right to Buy) | |
| Howard Horn | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2025 | 15,653 | 107,954 (0%) | 0% | 0 | Common Stock | |
| Erik Harris | EVP & Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 42.10 per share. | 01 Mar 2025 | 15,103 | 87,855 (0%) | 0% | 42.1 | 635,836 | Common Stock |
| Erik Harris | EVP & Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2025 | 18,443 | 102,419 (0%) | 0% | 0 | Common Stock | |
| Erik Harris | EVP & Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2025 | 16,813 | 83,976 (0%) | 0% | 0 | Common Stock | |
| Dennis Karl Huang | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2025 | 14,494 | 97,496 (0%) | 0% | 0 | Common Stock | |
| Eric Crombez | EVP and Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2025 | 16,813 | 65,244 (0%) | 0% | 0 | Common Stock | |
| Eric Crombez | EVP and Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2025 | 14,971 | 80,215 (0%) | 0% | 0 | Common Stock | |
| Eric Crombez | EVP and Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 42.10 per share. | 01 Mar 2025 | 8,945 | 71,922 (0%) | 0% | 42.1 | 376,585 | Common Stock |
| Eric Crombez | EVP and Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2025 | 30,246 | 30,246 | - | - | Stock Ooption (Right to Buy) | |
| John Richard Pinion | See Remarks | Payment of exercise price or tax liability using portion of securities received from the company at price $ 42.94 per share. | 01 Mar 2025 | 31 | 108,428 (0%) | 0% | 42.9 | 1,331 | Common Stock |
| John Richard Pinion | See Remarks | Sale of securities on an exchange or to another person at price $ 42.10 per share. | 01 Mar 2025 | 14,439 | 107,766 (0%) | 0% | 42.1 | 607,882 | Common Stock |
| John Richard Pinion | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2025 | 18,443 | 122,205 (0%) | 0% | 0 | Common Stock | |
| John Richard Pinion | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2025 | 14,494 | 103,762 (0%) | 0% | 0 | Common Stock | |
| John Richard Pinion | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2025 | 26,074 | 26,074 | - | - | Stock Option (Right to Buy) | |
| Dennis Karl Huang | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2025 | 26,074 | 26,074 | - | - | Stock Option (Right to Buy) | |
| Dennis Karl Huang | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2025 | 18,443 | 115,939 (0%) | 0% | 0 | Common Stock | |
| Thomas R. Kassberg | CBO & EVP | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2025 | 18,443 | 271,266 (0%) | 0% | 0 | Common Stock | |
| Thomas R. Kassberg | CBO & EVP | Payment of exercise price or tax liability using portion of securities received from the company at price $ 42.92 per share. | 01 Mar 2025 | 508 | 264,730 (0%) | 0% | 42.9 | 21,803 | Common Stock |
| Thomas R. Kassberg | CBO & EVP | Sale of securities on an exchange or to another person at price $ 42.10 per share. | 01 Mar 2025 | 6,028 | 265,238 (0%) | 0% | 42.1 | 253,779 | Common Stock |
| Theodore A. Huizenga | SVP, Chief Accounting Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 42.92 per share. | 01 Mar 2025 | 141 | 50,124 (0%) | 0% | 42.9 | 6,052 | Common Stock |
| Theodore A. Huizenga | SVP, Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 42.10 per share. | 01 Mar 2025 | 967 | 50,265 (0%) | 0% | 42.1 | 40,711 | Common Stock |
| Theodore A. Huizenga | SVP, Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2025 | 5,632 | 5,632 | - | - | Stock Option (Right to Buy) | |
| Theodore A. Huizenga | SVP, Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2025 | 9,392 | 51,232 (0%) | 0% | 0 | Common Stock | |
| Karah Parschauer | EVP and Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2025 | 18,443 | 88,133 (0%) | 0% | 0 | Common Stock | |
| Karah Parschauer | EVP and Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 42.10 per share. | 01 Mar 2025 | 12,846 | 75,287 (0%) | 0% | 42.1 | 540,817 | Common Stock |
| Dennis Karl Huang | See Remarks | Payment of exercise price or tax liability using portion of securities received from the company at price $ 42.92 per share. | 01 Mar 2025 | 1,348 | 114,591 (0%) | 0% | 42.9 | 57,856 | Common Stock |
| Emil D. Kakkis | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2025 | 43,268 | 607,873 (1%) | 0% | 0 | Common Stock | |
| Emil D. Kakkis | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2025 | 107,292 | 715,165 (1%) | 0% | 0 | Common Stock | |
| Emil D. Kakkis | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 42.10 per share. | 28 Feb 2025 | 73,434 | 641,731 (1%) | 0% | 42.1 | 3,091,571 | Common Stock |
| Emil D. Kakkis | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 42.48 per share. | 28 Feb 2025 | 25,000 | 2,158,985 (3%) | 0% | 42.5 | 1,062,000 | Common Stock |
| Emil D. Kakkis | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Feb 2025 | 78,448 | 78,448 | - | - | Stock Option (Right to Buy) | |
| Karah Parschauer | EVP and Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 42.93 per share. | 27 Feb 2025 | 2,230 | 55,751 (0%) | 0% | 42.9 | 95,734 | Common Stock |
| Karah Parschauer | EVP and Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 42.75 per share. | 27 Feb 2025 | 760 | 54,991 (0%) | 0% | 42.8 | 32,490 | Common Stock |
| Karah Parschauer | EVP and Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Feb 2025 | 14,494 | 69,690 (0%) | 0% | 0 | Common Stock | |
| Karah Parschauer | EVP and Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 27 Feb 2025 | 26,074 | 26,074 | - | - | Stock Option (Right to Buy) | |
| Emil D. Kakkis | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 42.23 per share. | 30 Dec 2024 | 11,727 | 2,183,985 (3%) | 0% | 42.2 | 495,231 | Common Stock |
| Theodore A. Huizenga | SVP, Chief Accounting Officer | Gift of securities by or to the insider at price $ 0.00 per share. | 10 Dec 2024 | 648 | 41,840 (0%) | 0% | 0 | Common Stock | |
| Emil D. Kakkis | Director, President & CEO | Gift of securities by or to the insider at price $ 0.00 per share. | 09 Dec 2024 | 20,000 | 2,203,985 (3%) | 0% | 0 | Common Stock | |
| Emil D. Kakkis | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 50.00 per share. | 09 Dec 2024 | 8,273 | 2,195,712 (3%) | 0% | 50 | 413,650 | Common Stock |
| Howard Horn | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 52.76 per share. | 10 Oct 2024 | 7,465 | 92,301 (0%) | 0% | 52.8 | 393,853 | Common Stock |
| Theodore A. Huizenga | SVP, Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Sep 2024 | 700 | 42,251 (0%) | 0% | 0 | Common Stock | |
| Emil D. Kakkis | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 55.85 per share. | 03 Sep 2024 | 20,000 | 2,223,985 (3%) | 0% | 55.9 | 1,117,000 | Common Stock |
| Theodore A. Huizenga | SVP, Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 56.19 per share. | 03 Sep 2024 | 91 | 41,551 (0%) | 0% | 56.2 | 5,113 | Common Stock |
| Emil D. Kakkis | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 50.17 per share. | 06 Aug 2024 | 20,000 | 2,243,985 (3%) | 0% | 50.2 | 1,003,400 | Common Stock |
| Corazon Dating Sanders | Director | Sale of securities on an exchange or to another person at price $ 40.98 per share. | 02 Jul 2024 | 584 | 12,009 (0%) | 0% | 41.0 | 23,932 | Common Stock |
| Deborah L. Dunsire | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Jun 2024 | 9,900 | 9,900 | - | - | Stock Option (Right to Buy) | |
| Deborah L. Dunsire | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Jun 2024 | 5,345 | 25,075 (0%) | 0% | 0 | Common Stock | |
| Matthew K. Fust | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Jun 2024 | 5,345 | 20,205 (0%) | 0% | 0 | Common Stock | |
| Matthew K. Fust | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Jun 2024 | 9,900 | 9,900 | - | - | Stock Option (Right to Buy) | |
| Daniel G. Welch | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Jun 2024 | 9,900 | 9,900 | - | - | Stock Option (Right to Buy) | |
| Daniel G. Welch | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Jun 2024 | 5,345 | 26,950 (0%) | 0% | 0 | Common Stock | |
| Michael A. Narachi | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Jun 2024 | 5,345 | 26,950 (0%) | 0% | 0 | Common Stock | |
| Michael A. Narachi | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Jun 2024 | 9,900 | 9,900 | - | - | Stock Option (Right to Buy) | |
| Shehnaaz Suliman | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Jun 2024 | 9,900 | 9,900 | - | - | Stock Option (Right to Buy) | |
| Shehnaaz Suliman | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Jun 2024 | 5,345 | 20,200 (0%) | 0% | 0 | Common Stock | |
| Corazon Dating Sanders | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Jun 2024 | 9,900 | 9,900 | - | - | Stock Option (Right to Buy) | |
| Corazon Dating Sanders | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Jun 2024 | 5,345 | 12,593 (0%) | 0% | 0 | Common Stock | |
| Amrit Ray | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Jun 2024 | 9,900 | 9,900 | - | - | Stock Option (Right to Buy) | |
| Amrit Ray | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Jun 2024 | 5,345 | 17,625 (0%) | 0% | 0 | Common Stock | |
| Karah Parschauer | EVP and Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 45.00 per share. | 12 Jun 2024 | 9,806 | 57,981 (0%) | 0% | 45 | 441,270 | Common Stock |
| Corazon Dating Sanders | Director | Sale of securities on an exchange or to another person at price $ 41.10 per share. | 10 Jun 2024 | 1,737 | 7,248 (0%) | 0% | 41.1 | 71,391 | Common Stock |
| Eric Crombez | EVP and Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 43.66 per share. | 02 May 2024 | 354 | 48,431 (0%) | 0% | 43.7 | 15,456 | Common Stock |
| Eric Crombez | EVP and Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 44.10 per share. | 18 Apr 2024 | 142 | 48,785 (0%) | 0% | 44.1 | 6,262 | Common Stock |
| Theodore A. Huizenga | SVP, Chief Accounting Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 42.29 per share. | 16 Apr 2024 | 14 | 41,366 (0%) | 0% | 42.3 | 592 | Common Stock |
| Thomas R. Kassberg | CBO & EVP | Sale of securities on an exchange or to another person at price $ 49.93 per share. | 11 Mar 2024 | 11,509 | 252,823 (0%) | 0% | 49.9 | 574,644 | Common Stock |
| Matthew K. Fust | Director | Sale of securities on an exchange or to another person at price $ 50.89 per share. | 07 Mar 2024 | 2,550 | 24,505 (0%) | 0% | 50.9 | 129,770 | Common Stock |
| Matthew K. Fust | Director | Sale of securities on an exchange or to another person at price $ 50.88 per share. | 07 Mar 2024 | 7,500 | 14,860 (0%) | 0% | 50.9 | 381,600 | Common Stock |
| Matthew K. Fust | Director | Sale of securities on an exchange or to another person at price $ 50.85 per share. | 07 Mar 2024 | 2,145 | 22,360 (0%) | 0% | 50.8 | 109,073 | Common Stock |
| Emil D. Kakkis | Director, President & CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 53.69 per share. | 01 Mar 2024 | 17,417 | 560,781 (0%) | 0% | 53.7 | 935,119 | Common Stock |
| Emil D. Kakkis | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 38,428 | 578,198 (0%) | 0% | 0 | Common Stock | |
| Emil D. Kakkis | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 70,094 | 70,094 | - | - | Stock Option (Right to Buy) | |
| Emil D. Kakkis | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 3,132 | 563,913 (0%) | 0% | 0 | Common Stock | |
| Thomas R. Kassberg | CBO & EVP | Sale of securities on an exchange or to another person at price $ 53.76 per share. | 01 Mar 2024 | 1,011 | 264,332 (0%) | 0% | 53.8 | 54,351 | Common Stock |
| Thomas R. Kassberg | CBO & EVP | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 31,400 | 31,400 | - | - | Stock Option (Right to Buy) | |
| Thomas R. Kassberg | CBO & EVP | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 17,800 | 264,660 (0%) | 0% | 0 | Common Stock | |
| Thomas R. Kassberg | CBO & EVP | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 957 | 265,617 (0%) | 0% | 0 | Common Stock | |
| Thomas R. Kassberg | CBO & EVP | Payment of exercise price or tax liability using portion of securities received from the company at price $ 53.69 per share. | 01 Mar 2024 | 274 | 265,343 (0%) | 0% | 53.7 | 14,711 | Common Stock |
| Theodore A. Huizenga | SVP, Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 2,351 | 2,351 | - | - | Stock Option (Right to Buy) | |
| Theodore A. Huizenga | SVP, Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 13,950 | 41,842 (0%) | 0% | 0 | Common Stock | |
| Theodore A. Huizenga | SVP, Chief Accounting Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 53.69 per share. | 01 Mar 2024 | 121 | 41,721 (0%) | 0% | 53.7 | 6,496 | Common Stock |
| Theodore A. Huizenga | SVP, Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 53.76 per share. | 01 Mar 2024 | 341 | 41,380 (0%) | 0% | 53.8 | 18,332 | Common Stock |
| Theodore A. Huizenga | SVP, Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 8,200 | 8,200 | - | - | Stock Option (Right to Buy) | |
| Karah Parschauer | EVP and Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 31,400 | 31,400 | - | - | Stock Option (Right to Buy) | |
| Karah Parschauer | EVP and Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 17,800 | 69,782 (0%) | 0% | 0 | Common Stock | |
| Karah Parschauer | EVP and Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 957 | 70,739 (0%) | 0% | 0 | Common Stock | |
| Karah Parschauer | EVP and Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 53.76 per share. | 01 Mar 2024 | 3,756 | 67,340 (0%) | 0% | 53.8 | 201,923 | Common Stock |
| Dennis Karl Huang | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 31,400 | 31,400 | - | - | Stock Option (Right to Buy) | |
| Dennis Karl Huang | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 17,800 | 82,515 (0%) | 0% | 0 | Common Stock | |
| Dennis Karl Huang | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 957 | 83,472 (0%) | 0% | 0 | Common Stock | |
| Dennis Karl Huang | See Remarks | Payment of exercise price or tax liability using portion of securities received from the company at price $ 53.69 per share. | 01 Mar 2024 | 470 | 83,002 (0%) | 0% | 53.7 | 25,234 | Common Stock |
| John Richard Pinion | See Remarks | Sale of securities on an exchange or to another person at price $ 53.76 per share. | 01 Mar 2024 | 4,173 | 89,268 (0%) | 0% | 53.8 | 224,340 | Common Stock |
| John Richard Pinion | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 31,400 | 31,400 | - | - | Stock Option (Right to Buy) | |
| John Richard Pinion | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 17,800 | 92,544 (0%) | 0% | 0 | Common Stock | |
| John Richard Pinion | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 957 | 93,501 (0%) | 0% | 0 | Common Stock | |
| John Richard Pinion | See Remarks | Payment of exercise price or tax liability using portion of securities received from the company at price $ 53.68 per share. | 01 Mar 2024 | 60 | 93,441 (0%) | 0% | 53.7 | 3,221 | Common Stock |
| Eric Crombez | EVP and Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 2,351 | 2,351 | - | - | Stock Option (Right to Buy) | |
| Eric Crombez | EVP and Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 19,400 | 49,912 (0%) | 0% | 0 | Common Stock | |
| Eric Crombez | EVP and Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 53.76 per share. | 01 Mar 2024 | 1,238 | 48,927 (0%) | 0% | 53.8 | 66,555 | Common Stock |
| Eric Crombez | EVP and Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 34,200 | 34,200 | - | - | Stock Option (Right to Buy) | |
| Erik Harris | EVP & Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 957 | 71,638 (0%) | 0% | 0 | Common Stock | |
| Erik Harris | EVP & Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 34,200 | 34,200 | - | - | Stock Option (Right to Buy) | |
| Erik Harris | EVP & Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 53.76 per share. | 01 Mar 2024 | 4,768 | 67,163 (0%) | 0% | 53.8 | 256,328 | Common Stock |
| Erik Harris | EVP & Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 19,400 | 70,681 (0%) | 0% | 0 | Common Stock | |
| Howard Horn | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 34,200 | 34,200 | - | - | Stock Option (Right to Buy) | |
| Howard Horn | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2024 | 19,400 | 99,766 (0%) | 0% | 0 | Common Stock | |
| Emil Kakkis D. | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 45.00 per share. | 07 Feb 2024 | 30,000 | 539,770 (0%) | 0% | 45 | 1,350,000 | Common Stock |
| Kakkis Emil D. | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 47.87 per share. | 29 Dec 2023 | 30,000 | 569,770 (0%) | 0% | 47.9 | 1,436,100 | Common Stock |
| Huizenga Theodore A. | SVP, Chief Accounting Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Dec 2023 | 3,000 | 0 | - | - | Stock Option (Right to Buy) | |
| Theodore Huizenga A. | SVP, Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 Dec 2023 | 1,000 | 24,614 (0%) | 0% | 0 | Common Stock | |
| Theodore A. Huizenga | SVP, Chief Accounting Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 21.00 per share. | 20 Dec 2023 | 3,000 | 27,892 (0%) | 0% | 21 | 63,000 | Common Stock |
| Corsee Dating Sanders | Director | Sale of securities on an exchange or to another person at price $ 46.76 per share. | 30 Jun 2023 | 585 | 8,985 (0%) | 0% | 46.8 | 27,355 | Common Stock |
| Erik Harris | EVP & Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 48.20 per share. | 19 Jun 2023 | 305 | 57,281 (0%) | 0% | 48.2 | 14,701 | Common Stock |
| Deborah L. Dunsire | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Jun 2023 | 7,110 | 7,110 | - | - | Stock Option (Right to Buy) | |
| Deborah L. Dunsire | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Jun 2023 | 3,860 | 19,730 (0%) | 0% | 0 | Common Stock | |
| Matthew K. Fust | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Jun 2023 | 7,110 | 7,110 | - | - | Stock Option (Right to Buy) | |
| Matthew K. Fust | Director | Sale or transfer of securities back to the company at price $ 51.82 per share. | 07 Jun 2023 | 3,300 | 27,055 (0%) | 0% | 51.8 | 171,006 | Common Stock |
| Matthew K. Fust | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Jun 2023 | 3,860 | 30,355 (0%) | 0% | 0 | Common Stock | |
| Daniel G. Welch | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Jun 2023 | 3,860 | 21,605 (0%) | 0% | 0 | Common Stock | |
| Daniel G. Welch | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Jun 2023 | 7,110 | 7,110 | - | - | Stock Option (Right to Buy) | |
| Michael A. Narachi | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Jun 2023 | 7,110 | 7,110 | - | - | Common Stock | |
| Michael A. Narachi | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Jun 2023 | 3,860 | 21,605 (0%) | 0% | 0 | Common Stock | |
| Shehnaaz Suliman | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Jun 2023 | 3,860 | 14,855 (0%) | 0% | 0 | Common Stock | |
| Shehnaaz Suliman | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Jun 2023 | 7,110 | 7,110 | - | - | Stock Option (Right to Buy) | |
| Corsee Dating Sanders | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Jun 2023 | 3,860 | 11,055 (0%) | 0% | 0 | Common Stock | |
| Corsee Dating Sanders | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Jun 2023 | 7,110 | 7,110 | - | - | Stock Option (Right to Buy) | |
| Corsee Dating Sanders | Director | Sale of securities on an exchange or to another person at price $ 51.65 per share. | 07 Jun 2023 | 1,485 | 9,570 (0%) | 0% | 51.6 | 76,700 | Common Stock |
| Amrit Ray | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Jun 2023 | 3,860 | 12,280 (0%) | 0% | 0 | Common Stock | |
| Amrit Ray | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 07 Jun 2023 | 7,110 | 7,110 | - | - | Stock Option (Right to Buy) | |
| John Richard Pinion | See Remarks | Sale of securities on an exchange or to another person at price $ 50.00 per share. | 18 May 2023 | 2,012 | 74,744 (0%) | 0% | 50 | 100,600 | Common Stock |
| Theodore A. Huizenga | SVP, Chief Accounting Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 21.00 per share. | 09 May 2023 | 3,000 | 30,747 (0%) | 0% | 21 | 63,000 | Common Stock |
| Theodore A. Huizenga | SVP, Chief Accounting Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 May 2023 | 3,000 | 5,000 | - | - | Stock Option (Right to Buy) | |
| Karah Parschauer | EVP and Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 45.00 per share. | 04 May 2023 | 4,378 | 51,982 (0%) | 0% | 45 | 197,010 | Common Stock |
| Eric Crombez | EVP and Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 May 2023 | 4,658 | 30,512 (0%) | 0% | 0 | Common Stock | |
| Eric Crombez | EVP and Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 May 2023 | 8,362 | 8,362 | - | - | Stock Option (Right to Buy) | |
| Theodore A. Huizenga | SVP, Chief Accounting Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 38.21 per share. | 16 Apr 2023 | 14 | 27,701 (0%) | 0% | 38.2 | 535 | Common Stock |
| Theodore A. Huizenga | SVP, Chief Accounting Officer | Sale or transfer of securities back to the company at price $ 38.20 per share. | 16 Apr 2023 | 181 | 27,520 (0%) | 0% | 38.2 | 6,914 | Common Stock |
| Emil D. Kakkis | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2023 | 46,200 | 615,606 (1%) | 0% | 0 | Common Stock | |
| Emil D. Kakkis | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2023 | 8,716 | 569,406 (0%) | 0% | 0 | Common Stock | |
| Emil D. Kakkis | Director, President & CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 45.65 per share. | 01 Mar 2023 | 16,140 | 599,176 (1%) | 0% | 45.7 | 736,791 | Common Stock |
| Emil D. Kakkis | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2023 | 83,500 | 83,500 | - | - | Stock Option (Right to Buy) | |
| Thomas R. Kassberg | CBO & EVP | Sale or transfer of securities back to the company at price $ 45.65 per share. | 01 Mar 2023 | 3,394 | 246,860 (0%) | 0% | 45.6 | 154,936 | Common Stock |
| Thomas R. Kassberg | CBO & EVP | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2023 | 39,400 | 39,400 | - | - | Stock Option (Right to Buy) | |
| Thomas R. Kassberg | CBO & EVP | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2023 | 2,663 | 230,222 (0%) | 0% | 0 | Common Stock | |
| Thomas R. Kassberg | CBO & EVP | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2023 | 22,000 | 252,222 (0%) | 0% | 0 | Common Stock | |
| Thomas R. Kassberg | CBO & EVP | Sale of securities on an exchange or to another person at price $ 45.27 per share. | 01 Mar 2023 | 1,968 | 250,254 (0%) | 0% | 45.3 | 89,091 | Common Stock |
| Camille L. Bedrosian | EVP and Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2023 | 2,663 | 50,601 (0%) | 0% | 0 | Common Stock | |
| Camille L. Bedrosian | EVP and Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 45.25 per share. | 01 Mar 2023 | 3,881 | 46,720 (0%) | 0% | 45.2 | 175,615 | Common Stock |
| Theodore A. Huizenga | SVP, Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2023 | 10,120 | 10,120 | - | - | Stock Option (Right to Buy) | |
| Theodore A. Huizenga | SVP, Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2023 | 7,590 | 23,148 (0%) | 0% | 0 | Common Stock | |
| Theodore A. Huizenga | SVP, Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 45.65 per share. | 01 Mar 2023 | 100 | 23,048 (0%) | 0% | 45.7 | 4,565 | Common Stock |
| Theodore A. Huizenga | SVP, Chief Accounting Officer | Sale or transfer of securities back to the company at price $ 45.65 per share. | 01 Mar 2023 | 1,333 | 21,715 (0%) | 0% | 45.6 | 60,851 | Common Stock |
| Karah Parschauer | EVP and Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2023 | 39,400 | 39,400 | - | - | Stock Option (Right to Buy) | |
| Karah Parschauer | EVP and Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2023 | 2,663 | 37,101 (0%) | 0% | 0 | Common Stock | |
| Karah Parschauer | EVP and Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 45.25 per share. | 01 Mar 2023 | 3,161 | 56,139 (0%) | 0% | 45.2 | 143,035 | Common Stock |
| Karah Parschauer | EVP and Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2023 | 22,000 | 59,101 (0%) | 0% | 0 | Common Stock | |
| Dennis Karl Huang | See Remarks | Sale or transfer of securities back to the company at price $ 45.65 per share. | 01 Mar 2023 | 10,599 | 64,715 (0%) | 0% | 45.6 | 483,844 | Common Stock |
| Dennis Karl Huang | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2023 | 39,400 | 39,400 | - | - | Stock Option (Right to Buy) | |
| Dennis Karl Huang | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2023 | 2,663 | 53,703 (0%) | 0% | 0 | Common Stock | |
| Dennis Karl Huang | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2023 | 22,000 | 75,703 (0%) | 0% | 0 | Common Stock | |
| Dennis Karl Huang | See Remarks | Sale of securities on an exchange or to another person at price $ 45.65 per share. | 01 Mar 2023 | 389 | 75,314 (0%) | 0% | 45.7 | 17,758 | Common Stock |
| John Richard Pinion | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2023 | 22,000 | 83,929 (0%) | 0% | 0 | Common Stock | |
| John Richard Pinion | See Remarks | Sale or transfer of securities back to the company at price $ 45.65 per share. | 01 Mar 2023 | 4,014 | 76,160 (0%) | 0% | 45.6 | 183,239 | Common Stock |
| John Richard Pinion | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2023 | 39,400 | 39,400 | - | - | 3/1/2023 | |
| John Richard Pinion | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2023 | 2,663 | 61,929 (0%) | 0% | 0 | Common Stock | |
| John Richard Pinion | See Remarks | Sale of securities on an exchange or to another person at price $ 45.26 per share. | 01 Mar 2023 | 3,755 | 80,174 (0%) | 0% | 45.3 | 169,951 | Common Stock |
| Erik Harris | EVP & Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 45.25 per share. | 01 Mar 2023 | 3,664 | 57,344 (0%) | 0% | 45.3 | 165,796 | Common Stock |
| Erik Harris | EVP & Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2023 | 39,400 | 39,400 | - | - | Stock Option (Right to Buy) | |
| Erik Harris | EVP & Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2023 | 2,663 | 38,823 (0%) | 0% | 0 | Common Stock | |
| Erik Harris | EVP & Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2023 | 22,000 | 60,823 (0%) | 0% | 0 | Common Stock | |
| Theodore A. Huizenga | SVP, Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 43.40 per share. | 28 Feb 2023 | 639 | 15,558 (0%) | 0% | 43.4 | 27,733 | Common Stock |
| Emil D. Kakkis | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 45.57 per share. | 30 Dec 2022 | 19,582 | 541,108 (0%) | 0% | 45.6 | 892,352 | Common Stock |
| Theodore A. Huizenga | SVP, Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 43.96 per share. | 21 Dec 2022 | 2,031 | 16,197 (0%) | 0% | 44.0 | 89,283 | Common Stock |
| Mardi C. Dier | CFO & Executive Vice President | Sale of securities on an exchange or to another person at price $ 40.16 per share. | 14 Oct 2022 | 1,629 | 66,695 (0%) | 0% | 40.2 | 65,421 | Common Stock |
| Mardi C. Dier | CFO & Executive Vice President | Sale of securities on an exchange or to another person at price $ 38.22 per share. | 12 Oct 2022 | 3,484 | 68,324 (0%) | 0% | 38.2 | 133,158 | Common Stock |
| Mardi C. Dier | CFO & Executive Vice President | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Sep 2022 | 20,000 | 71,808 (0%) | 0% | 0 | Common Stock | |
| Theodore A. Huizenga | SVP, Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Sep 2022 | 1,000 | 18,094 (0%) | 0% | 0 | Common Stock | |
| Deborah L. Dunsire | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Jun 2022 | 3,300 | 15,870 (0%) | 0% | 0 | Common Stock | |
| Deborah L. Dunsire | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Jun 2022 | 6,245 | 6,245 | - | - | Stock Option (Right to Buy) | |
| Matthew K. Fust | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Jun 2022 | 6,245 | 6,245 | - | - | Stock Option (Right to Buy) | |
| Matthew K. Fust | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Jun 2022 | 3,300 | 26,495 (0%) | 0% | 0 | Common Stock | |
| Daniel G. Welch | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Jun 2022 | 6,245 | 6,245 | - | - | Stock Option (Right to Buy) | |
| Daniel G. Welch | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Jun 2022 | 3,300 | 17,745 (0%) | 0% | 0 | Common Stock | |
| Michael A. Narachi | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Jun 2022 | 3,300 | 17,745 (0%) | 0% | 0 | Common Stock | |
| Michael A. Narachi | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Jun 2022 | 6,245 | 6,245 | - | - | Stock Option (Right to Buy) | |
| Lars G. Ekman | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Jun 2022 | 6,245 | 6,245 | - | - | Stock Option (Right to Buy) | |
| Lars G. Ekman | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Jun 2022 | 3,300 | 17,745 (0%) | 0% | 0 | Common Stock | |
| Shehnaaz Suliman | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Jun 2022 | 6,245 | 6,245 | - | - | Stock Option (Right to Buy) | |
| Shehnaaz Suliman | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Jun 2022 | 3,300 | 10,995 (0%) | 0% | 0 | Common Stock | |
| Corazon Dating Sanders | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Jun 2022 | 3,300 | 7,195 (0%) | 0% | 0 | Common Stock | |
| Corazon Dating Sanders | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Jun 2022 | 6,245 | 6,245 | - | - | Stock Option (Right to Buy) | |
| Amrit Ray | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Jun 2022 | 3,300 | 8,420 (0%) | 0% | 0 | Common Stock | |
| Amrit Ray | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Jun 2022 | 6,245 | 6,245 | - | - | Stock Option (Right to Buy) | |
| Erik Harris | EVP & Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 54.78 per share. | 19 Jun 2022 | 295 | 36,160 (0%) | 0% | 54.8 | 16,160 | Common Stock |
| Amrit Ray | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Apr 2022 | 5,120 | 5,120 (0%) | 0% | 0 | Common Stock | |
| Amrit Ray | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Apr 2022 | 9,525 | 9,525 | - | - | Stock Option (Right to Buy) | |
| Theodore A. Huizenga | SVP, Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 84.55 per share. | 16 Apr 2022 | 132 | 16,914 (0%) | 0% | 84.6 | 11,161 | Common Stock |
| Thomas R. Kassberg | CBO & EVP | Sale of securities on an exchange or to another person at price $ 67.01 per share. | 11 Mar 2022 | 10,281 | 227,559 (0%) | 0% | 67.0 | 688,930 | Common Stock |
| Karah Parschauer | EVP and Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 62.95 per share. | 07 Mar 2022 | 5,140 | 34,438 (0%) | 0% | 63.0 | 323,563 | Common Stock |
| Matthew K. Fust | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 40.37 per share. | 04 Mar 2022 | 7,500 | 23,195 (0%) | 0% | 40.4 | 302,775 | Common Stock |
| Matthew K. Fust | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Mar 2022 | 7,500 | 0 | - | - | Stock Option (Right to Buy) | |
| Emil D. Kakkis | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2022 | 92,360 | 92,360 | - | - | Stock Option (Right to Buy) | |
| Emil D. Kakkis | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2022 | 52,041 | 634,226 (1%) | 0% | 0 | Common Stock | |
| Emil D. Kakkis | Director, President & CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 67.37 per share. | 01 Mar 2022 | 12,162 | 582,185 (1%) | 0% | 67.4 | 819,354 | Common Stock |
| Thomas R. Kassberg | CBO & EVP | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2022 | 24,900 | 24,900 | - | - | Stock Option (Right to Buy) | |
| Thomas R. Kassberg | CBO & EVP | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2022 | 14,000 | 227,840 (0%) | 0% | 0 | Common Stock | |
| Thomas R. Kassberg | CBO & EVP | Sale of securities on an exchange or to another person at price $ 66.62 per share. | 01 Mar 2022 | 2,374 | 213,840 (0%) | 0% | 66.6 | 158,156 | Common Stock |
| Camille L. Bedrosian | EVP and Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2022 | 24,900 | 24,900 | - | - | Stock Option (Right to Buy) | |
| Camille L. Bedrosian | EVP and Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2022 | 14,000 | 47,938 (0%) | 0% | 0 | Common Stock | |
| Camille L. Bedrosian | EVP and Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 66.62 per share. | 01 Mar 2022 | 2,821 | 33,938 (0%) | 0% | 66.6 | 187,935 | Common Stock |
| Mardi C. Dier | CFO & Executive Vice President | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2022 | 24,900 | 24,900 | - | - | Stock Option (Right to Buy) | |
| Mardi C. Dier | CFO & Executive Vice President | Sale of securities on an exchange or to another person at price $ 66.62 per share. | 01 Mar 2022 | 534 | 38,228 (0%) | 0% | 66.6 | 35,575 | Common Stock |
| Mardi C. Dier | CFO & Executive Vice President | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2022 | 14,000 | 52,228 (0%) | 0% | 0 | Common Stock | |
| Mardi C. Dier | CFO & Executive Vice President | Sale of securities on an exchange or to another person at price $ 64.55 per share. | 01 Mar 2022 | 420 | 51,808 (0%) | 0% | 64.6 | 27,111 | Common Stock |
| Theodore A. Huizenga | SVP, Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2022 | 7,400 | 7,400 | - | - | Stock Option (Right to Buy) | |
| Theodore A. Huizenga | SVP, Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 66.62 per share. | 01 Mar 2022 | 843 | 13,229 (0%) | 0% | 66.6 | 56,161 | Common Stock |
| Theodore A. Huizenga | SVP, Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2022 | 3,710 | 17,046 (0%) | 0% | 0 | Common Stock | |
| Karah Parschauer | EVP and Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2022 | 14,000 | 39,578 (0%) | 0% | 0 | Common Stock | |
| Karah Parschauer | EVP and Chief Legal Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2022 | 24,900 | 24,900 | - | - | Stock Option (Right to Buy) | |
| Karah Parschauer | EVP and Chief Legal Officer | Sale of securities on an exchange or to another person at price $ 66.62 per share. | 01 Mar 2022 | 2,886 | 25,472 (0%) | 0% | 66.6 | 192,265 | Common Stock |
| Dennis Karl Huang | See Remarks | Sale of securities on an exchange or to another person at price $ 66.62 per share. | 01 Mar 2022 | 3,234 | 36,914 (0%) | 0% | 66.6 | 215,449 | Common Stock |
| Dennis Karl Huang | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2022 | 14,000 | 51,040 (0%) | 0% | 0 | Common Stock | |
| Dennis Karl Huang | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2022 | 24,900 | 24,900 | - | - | Stock Option (Right to Buy) | |
| John Richard Pinion | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2022 | 24,900 | 24,900 | - | - | Stock Option (Right to Buy) | |
| John Richard Pinion | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2022 | 14,000 | 59,266 (0%) | 0% | 0 | Common Stock | |
| John Richard Pinion | See Remarks | Sale of securities on an exchange or to another person at price $ 66.62 per share. | 01 Mar 2022 | 4,498 | 45,266 (0%) | 0% | 66.6 | 299,657 | Common Stock |
| Erik Harris | EVP & Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2022 | 14,000 | 36,317 (0%) | 0% | 0 | Common Stock | |
| Erik Harris | EVP & Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2022 | 24,900 | 24,900 | - | - | Stock Option (Right to Buy) | |
| Erik Harris | EVP & Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 66.62 per share. | 01 Mar 2022 | 2,713 | 22,317 (0%) | 0% | 66.6 | 180,740 | Common Stock |
| Camille L. Bedrosian | EVP and Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 66.30 per share. | 30 Jan 2022 | 1,657 | 36,759 (0%) | 0% | 66.3 | 109,859 | Common Stock |
| Emil D. Kakkis | Director, President & CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 81.00 per share. | 14 Oct 2021 | 853 | 594,347 (1%) | 0% | 81 | 69,093 | Common Stock |
| Thomas R. Kassberg | CBO & EVP | Sale of securities on an exchange or to another person at price $ 81.14 per share. | 14 Oct 2021 | 286 | 216,266 (0%) | 0% | 81.1 | 23,206 | Common Stock |
| Camille L. Bedrosian | EVP and Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 81.14 per share. | 14 Oct 2021 | 359 | 38,416 (0%) | 0% | 81.1 | 29,129 | Common Stock |
| Theodore A. Huizenga | SVP, Chief Accounting Officer | Gift of securities by or to the insider at price $ 0.00 per share. | 14 Oct 2021 | 819 | 14,212 (0%) | 0% | 0 | Common Stock | |
| Theodore A. Huizenga | SVP, Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 81.14 per share. | 14 Oct 2021 | 140 | 14,072 (0%) | 0% | 81.1 | 11,360 | Common Stock |
| Karah Parschauer | EVP and General Counsel | Sale of securities on an exchange or to another person at price $ 81.14 per share. | 14 Oct 2021 | 310 | 28,358 (0%) | 0% | 81.1 | 25,153 | Common Stock |
| Dennis Karl Huang | EVP & Chief Tech Ops Officer | Sale of securities on an exchange or to another person at price $ 81.14 per share. | 14 Oct 2021 | 358 | 40,148 (0%) | 0% | 81.1 | 29,048 | Common Stock |
| John Richard Pinion | See Remarks | Sale of securities on an exchange or to another person at price $ 81.14 per share. | 14 Oct 2021 | 358 | 49,764 (0%) | 0% | 81.1 | 29,048 | Common Stock |
| Erik Harris | EVP & Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 81.14 per share. | 14 Oct 2021 | 303 | 25,030 (0%) | 0% | 81.1 | 24,585 | Common Stock |
| Mardi C. Dier | CFO & Executive Vice President | Sale of securities on an exchange or to another person at price $ 81.16 per share. | 12 Oct 2021 | 3,261 | 38,762 (0%) | 0% | 81.2 | 264,663 | Common Stock |
| Mardi C. Dier | CFO & Executive Vice President | Sale of securities on an exchange or to another person at price $ 82.79 per share. | 12 Oct 2021 | 3,477 | 42,023 (0%) | 0% | 82.8 | 287,861 | Common Stock |
| Thomas R. Kassberg | CBO & EVP | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Sep 2021 | 109,734 | 0 | - | - | Stock Option (Right to Buy) | |
| Thomas R. Kassberg | CBO & EVP | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.31 per share. | 30 Sep 2021 | 109,734 | 216,552 (0%) | 0% | 0.3 | 34,018 | Common Stock |
| Karah Parschauer | EVP and General Counsel | Sale of securities on an exchange or to another person at price $ 100.65 per share. | 08 Sep 2021 | 7,336 | 28,668 (0%) | 0% | 100.6 | 738,368 | Common Stock |
| Karah Parschauer | EVP and General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Sep 2021 | 7,336 | 17,664 | - | - | Stock Option (Right to Buy) | |
| Karah Parschauer | EVP and General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 54.50 per share. | 08 Sep 2021 | 7,336 | 36,004 (0%) | 0% | 54.5 | 399,812 | Common Stock |
| Camille L. Bedrosian | EVP and Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 55.00 per share. | 01 Sep 2021 | 2,500 | 41,275 (0%) | 0% | 55 | 137,500 | Common Stock |
| Camille L. Bedrosian | EVP and Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Sep 2021 | 2,500 | 53,000 | - | - | Stock Option (Right to Buy) | |
| Camille L. Bedrosian | EVP and Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Sep 2021 | 2,500 | 55,500 | - | - | Stock Option (Right to Buy) | |
| Camille L. Bedrosian | EVP and Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 100.18 per share. | 01 Sep 2021 | 2,500 | 38,775 (0%) | 0% | 100.2 | 250,450 | Common Stock |
| Camille L. Bedrosian | EVP and Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 55.00 per share. | 01 Sep 2021 | 2,500 | 41,275 (0%) | 0% | 55 | 137,500 | Common Stock |
| Camille L. Bedrosian | EVP and Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 100.03 per share. | 01 Sep 2021 | 2,500 | 38,775 (0%) | 0% | 100.0 | 250,075 | Common Stock |
| Erik Harris | EVP & Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 91.53 per share. | 06 Jul 2021 | 375 | 25,333 (0%) | 0% | 91.5 | 34,324 | Common Stock |
| Corazon Dating Sanders | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Jun 2021 | 7,255 | 7,255 | - | - | Stock Option (Right to Buy) | |
| Corazon Dating Sanders | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 29 Jun 2021 | 3,895 | 3,895 (0%) | 0% | 0 | Common Stock | |
| Deborah L. Dunsire | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Jun 2021 | 4,125 | 4,125 | - | - | Stock Option (Right to Buy) | |
| Deborah L. Dunsire | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Jun 2021 | 2,145 | 12,570 (0%) | 0% | 0 | Common stock | |
| Matthew K. Fust | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Jun 2021 | 4,125 | 4,125 | - | - | Stock Option (Right to Buy) | |
| Matthew K. Fust | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Jun 2021 | 2,145 | 15,695 (0%) | 0% | 0 | Common Stock | |
| Daniel G. Welch | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Jun 2021 | 2,145 | 14,445 (0%) | 0% | 0 | Common Stock | |
| Daniel G. Welch | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Jun 2021 | 4,125 | 4,125 | - | - | Stock Option (Right to Buy) | |
| Michael A. Narachi | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Jun 2021 | 2,145 | 14,445 (0%) | 0% | 0 | Common Stock | |
| Michael A. Narachi | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Jun 2021 | 4,125 | 4,125 | - | - | Stock Option (Right to Buy) | |
| Lars G. Ekman | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Jun 2021 | 2,145 | 14,445 (0%) | 0% | 0 | Common Stock | |
| Lars G. Ekman | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Jun 2021 | 4,125 | 4,125 | - | - | Stock Option (Right to Buy) | |
| William E. Aliski | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Jun 2021 | 2,145 | 66,849 (0%) | 0% | 0 | Common Stock | |
| William E. Aliski | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Jun 2021 | 4,125 | 4,125 | - | - | Stock Option (Right to Buy) | |
| Shehnaaz Suliman | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Jun 2021 | 2,145 | 7,695 (0%) | 0% | 0 | Common Stock | |
| Shehnaaz Suliman | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Jun 2021 | 4,125 | 4,125 | - | - | Stock Option (Right to Buy) | |
| Erik Harris | EVP & Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 94.96 per share. | 19 Jun 2021 | 572 | 25,708 (0%) | 0% | 95.0 | 54,317 | Common Stock |
| Erik Harris | EVP & Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 94.63 per share. | 19 Jun 2021 | 437 | 26,280 (0%) | 0% | 94.6 | 41,353 | Common Stock |
| Emil D. Kakkis | Director, President & CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 115.71 per share. | 06 May 2021 | 852 | 595,200 (1%) | 0% | 115.7 | 98,585 | Common Stock |
| Thomas R. Kassberg | CBO & EVP | Sale of securities on an exchange or to another person at price $ 113.69 per share. | 06 May 2021 | 363 | 106,818 (0%) | 0% | 113.7 | 41,269 | Common Stock |
| Camille L. Bedrosian | EVP and Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 113.67 per share. | 06 May 2021 | 364 | 38,775 (0%) | 0% | 113.7 | 41,376 | Common Stock |
| Theodore A. Huizenga | SVP, Chief Accounting Officer | Sale of securities on an exchange or to another person at price $ 113.67 per share. | 06 May 2021 | 142 | 15,031 (0%) | 0% | 113.7 | 16,141 | Common Stock |
| Karah Parschauer | EVP and General Counsel | Sale of securities on an exchange or to another person at price $ 113.67 per share. | 06 May 2021 | 313 | 29,997 (0%) | 0% | 113.7 | 35,579 | Common Stock |
| Dennis Karl Huang | EVP & Chief Tech Ops Officer | Sale of securities on an exchange or to another person at price $ 113.68 per share. | 06 May 2021 | 363 | 40,506 (0%) | 0% | 113.7 | 41,266 | Common Stock |
| John Richard Pinion | See Remarks | Sale of securities on an exchange or to another person at price $ 113.69 per share. | 06 May 2021 | 363 | 50,122 (0%) | 0% | 113.7 | 41,269 | Common Stock |
| Erik Harris | EVP & Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 113.67 per share. | 06 May 2021 | 393 | 26,717 (0%) | 0% | 113.7 | 44,672 | Common Stock |
| Erik Harris | EVP & Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 113.68 per share. | 06 May 2021 | 307 | 27,110 (0%) | 0% | 113.7 | 34,900 | Common Stock |
| Emil D. Kakkis | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 107.80 per share. | 03 May 2021 | 30,000 | 2,259,741 (3%) | 0% | 107.8 | 3,234,000 | Common Stock |
| Erik Harris | EVP & Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 104.28 per share. | 20 Apr 2021 | 396 | 27,417 (0%) | 0% | 104.3 | 41,295 | Common Stock |
| Theodore A. Huizenga | SVP, Chief Accounting Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Apr 2021 | 1,500 | 15,044 (0%) | 0% | 0 | Common Stock | |
| Camille L. Bedrosian | EVP and Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Apr 2021 | 5,000 | 58,000 | - | - | Stock Option | |
| Camille L. Bedrosian | EVP and Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 109.09 per share. | 15 Apr 2021 | 5,000 | 39,139 (0%) | 0% | 109.1 | 545,450 | Common Stock |
| Camille L. Bedrosian | EVP and Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 55.00 per share. | 15 Apr 2021 | 5,000 | 44,139 (0%) | 0% | 55 | 275,000 | Common Stock |
| Theodore A. Huizenga | SVP, Controller and PAO | Sale of securities on an exchange or to another person at price $ 120.69 per share. | 08 Mar 2021 | 3,000 | 13,544 (0%) | 0% | 120.7 | 362,070 | Common Stock |
| Emil D. Kakkis | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2021 | 36,000 | 36,000 | - | - | Stock Option (Right to Buy) | |
| Emil D. Kakkis | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2021 | 18,000 | 596,941 (1%) | 0% | 0 | Common Stock | |
| Emil D. Kakkis | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2021 | 15,453 | 612,394 (1%) | 0% | 0 | Common Stock | |
| Emil D. Kakkis | Director, President & CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 142.47 per share. | 01 Mar 2021 | 16,342 | 596,052 (1%) | 0% | 142.5 | 2,328,245 | Common Stock |
| Emil D. Kakkis | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 141.80 per share. | 01 Mar 2021 | 30,000 | 2,289,741 (3%) | 0% | 141.8 | 4,254,000 | Common Stock |
| Thomas R. Kassberg | CBO & EVP | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2021 | 11,000 | 11,000 | - | - | Stock Option (Right to Buy) | |
| Thomas R. Kassberg | CBO & EVP | Sale of securities on an exchange or to another person at price $ 138.17 per share. | 01 Mar 2021 | 4,572 | 107,181 (0%) | 0% | 138.2 | 631,713 | Common Stock |
| Thomas R. Kassberg | CBO & EVP | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2021 | 4,636 | 111,614 (0%) | 0% | 0 | Common Stock | |
| Thomas R. Kassberg | CBO & EVP | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2021 | 5,500 | 106,978 (0%) | 0% | 0 | Common Stock | |
| Camille L. Bedrosian | EVP and Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 138.18 per share. | 01 Mar 2021 | 4,543 | 39,139 (0%) | 0% | 138.2 | 627,752 | Common Stock |
| Camille L. Bedrosian | EVP and Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2021 | 5,500 | 39,046 (0%) | 0% | 0 | Common Stock | |
| Camille L. Bedrosian | EVP and Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2021 | 4,636 | 43,682 (0%) | 0% | 0 | Common Stock | |
| Camille L. Bedrosian | EVP and Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2021 | 11,000 | 11,000 | - | - | Stock Option (Right o Buy) | |
| Mardi C. Dier | CFO & Executive Vice President | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2021 | 5,500 | 45,500 (0%) | 0% | 0 | Common Stock | |
| Mardi C. Dier | CFO & Executive Vice President | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2021 | 11,000 | 11,000 | - | - | Stock Option (Right to Buy) | |
| Theodore A. Huizenga | SVP, Controller and PAO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2021 | 4,655 | 4,655 | - | - | Stock Option (Right to Buy) | |
| Theodore A. Huizenga | SVP, Controller and PAO | Sale of securities on an exchange or to another person at price $ 138.17 per share. | 01 Mar 2021 | 732 | 16,544 (0%) | 0% | 138.2 | 101,140 | Common Stock |
| Theodore A. Huizenga | SVP, Controller and PAO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2021 | 1,560 | 17,276 (0%) | 0% | 0 | Common Stock | |
| Karah Parschauer | EVP and General Counsel | Sale of securities on an exchange or to another person at price $ 138.17 per share. | 01 Mar 2021 | 3,970 | 30,227 (0%) | 0% | 138.2 | 548,535 | Common Stock |
| Karah Parschauer | EVP and General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2021 | 11,000 | 11,000 | - | - | Stock Option (Right to Buy) | |
| Karah Parschauer | EVP and General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2021 | 5,500 | 29,561 (0%) | 0% | 0 | Common Stock | |
| Karah Parschauer | EVP and General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2021 | 4,636 | 34,197 (0%) | 0% | 0 | Common Stock | |
| Dennis Karl Huang | EVP & Chief Tech Ops Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2021 | 5,500 | 40,199 (0%) | 0% | 0 | Common Stock | |
| Dennis Karl Huang | EVP & Chief Tech Ops Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2021 | 4,636 | 44,835 (0%) | 0% | 0 | Common Stock | |
| Dennis Karl Huang | EVP & Chief Tech Ops Officer | Sale of securities on an exchange or to another person at price $ 138.18 per share. | 01 Mar 2021 | 4,255 | 40,761 (0%) | 0% | 138.2 | 587,956 | Common Stock |
| Dennis Karl Huang | EVP & Chief Tech Ops Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2021 | 11,000 | 11,000 | - | - | Stock Option (Right to Buy) | |
| John Richard Pinion | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2021 | 5,500 | 51,799 (0%) | 0% | 0 | Common Stock | |
| John Richard Pinion | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2021 | 11,000 | 11,000 | - | - | Stock Option (Right to Buy) | |
| John Richard Pinion | See Remarks | Sale of securities on an exchange or to another person at price $ 138.17 per share. | 01 Mar 2021 | 6,198 | 50,237 (0%) | 0% | 138.2 | 856,378 | Common Stock |
| John Richard Pinion | See Remarks | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2021 | 4,636 | 56,435 (0%) | 0% | 0 | Common Stock | |
| Erik Harris | EVP & Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2021 | 11,000 | 11,000 | - | - | Stock Option (Right to Buy) | |
| Erik Harris | EVP & Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 138.17 per share. | 01 Mar 2021 | 2,470 | 28,520 (0%) | 0% | 138.2 | 341,280 | Common Stock |
| Erik Harris | EVP & Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2021 | 4,636 | 30,990 (0%) | 0% | 0 | Common Stock | |
| Erik Harris | EVP & Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2021 | 5,500 | 26,354 (0%) | 0% | 0 | Common Stock | |
| Erik Harris | EVP & Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 138.16 per share. | 01 Mar 2021 | 707 | 27,813 (0%) | 0% | 138.2 | 97,679 | Common Stock |
| William E. Aliski | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 19 Feb 2021 | 7,500 | 0 | - | - | Stock Option (Right to Buy) | |
| William E. Aliski | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 97.85 per share. | 19 Feb 2021 | 7,500 | 73,204 (0%) | 0% | 97.9 | 733,875 | Common Stock |
| William E. Aliski | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 19 Feb 2021 | 1,000 | 64,704 (0%) | 0% | 0 | Common Stock | |
| William E. Aliski | Director | Sale of securities on an exchange or to another person at price $ 149.01 per share. | 19 Feb 2021 | 7,500 | 65,704 (0%) | 0% | 149.0 | 1,117,575 | Common Stock |
| Camille L. Bedrosian | EVP and Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 140.36 per share. | 30 Jan 2021 | 2,243 | 33,546 (0%) | 0% | 140.4 | 314,827 | Common Stock |
| Camille L. Bedrosian | EVP and Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 139.18 per share. | 15 Jan 2021 | 25,000 | 35,789 (0%) | 0% | 139.2 | 3,479,500 | Common Stock |
| Camille L. Bedrosian | EVP and Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Jan 2021 | 25,000 | 63,000 | - | - | Stock Option (Right to Buy) | |
| Camille L. Bedrosian | EVP and Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 55.00 per share. | 15 Jan 2021 | 25,000 | 60,789 (0%) | 0% | 55 | 1,375,000 | Common Stock |
| Theodore A. Huizenga | SVP, Controller and PAO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 21.00 per share. | 07 Jan 2021 | 4,000 | 20,436 (0%) | 0% | 21 | 84,000 | Common Stock |
| Theodore A. Huizenga | SVP, Controller and PAO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Jan 2021 | 4,000 | 8,000 | - | - | Stock Option | |
| Theodore A. Huizenga | SVP, Controller and PAO | Sale of securities on an exchange or to another person at price $ 140.65 per share. | 07 Jan 2021 | 4,000 | 15,716 (0%) | 0% | 140.7 | 562,600 | Common Stock |
| Emil D. Kakkis | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 136.90 per share. | 04 Jan 2021 | 30,000 | 2,329,741 (4%) | 0% | 136.9 | 4,107,000 | Common Stock |
| Karah Parschauer | EVP and General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 54.50 per share. | 30 Oct 2020 | 9,903 | 33,871 (0%) | 0% | 54.5 | 539,714 | Common Stock |
| Karah Parschauer | EVP and General Counsel | Sale of securities on an exchange or to another person at price $ 100.12 per share. | 30 Oct 2020 | 9,903 | 24,061 (0%) | 0% | 100.1 | 991,488 | Common Stock |
| Karah Parschauer | EVP and General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Oct 2020 | 9,903 | 25,000 | - | - | Stock Option (Right to Buy) | |
| Karah Parschauer | EVP and General Counsel | Sale of securities on an exchange or to another person at price $ 100.00 per share. | 28 Oct 2020 | 97 | 23,968 (0%) | 0% | 100 | 9,700 | Common Stock |
| Karah Parschauer | EVP and General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 54.51 per share. | 28 Oct 2020 | 97 | 24,065 (0%) | 0% | 54.5 | 5,287 | Common Stock |
| Karah Parschauer | EVP and General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Oct 2020 | 97 | 34,903 | - | - | Stock Option (Right to Buy) | |
| Shalini Sharp | EVP, Finance | Sale of securities on an exchange or to another person at price $ 87.99 per share. | 14 Oct 2020 | 375 | 97,812 (0%) | 0% | 88.0 | 32,996 | Common Stock |
| Emil D. Kakkis | Director, President & CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 92.69 per share. | 14 Oct 2020 | 852 | 610,189 (1%) | 0% | 92.7 | 78,972 | Common Stock |
| Thomas R. Kassberg | CBO & EVP | Sale of securities on an exchange or to another person at price $ 87.98 per share. | 14 Oct 2020 | 262 | 101,478 (0%) | 0% | 88.0 | 23,051 | Common Stock |
| Camille L. Bedrosian | EVP and Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 88.00 per share. | 14 Oct 2020 | 262 | 35,789 (0%) | 0% | 88 | 23,056 | Common Stock |
| Theodore A. Huizenga | SVP, Controller and PAO | Sale of securities on an exchange or to another person at price $ 87.98 per share. | 14 Oct 2020 | 146 | 16,436 (0%) | 0% | 88.0 | 12,845 | Common Stock |
| Karah Parschauer | EVP and General Counsel | Sale of securities on an exchange or to another person at price $ 88.00 per share. | 14 Oct 2020 | 325 | 23,968 (0%) | 0% | 88 | 28,600 | Common Stock |
| Dennis Karl Huang | EVP & Chief Tech Ops Officer | Sale of securities on an exchange or to another person at price $ 88.00 per share. | 14 Oct 2020 | 262 | 34,699 (0%) | 0% | 88 | 23,056 | Common Stock |
| John Richard Pinion | See Remarks | Sale of securities on an exchange or to another person at price $ 88.00 per share. | 14 Oct 2020 | 262 | 46,299 (0%) | 0% | 88 | 23,056 | Common Stock |
| Erik Harris | EVP & Chief Commercial Officer | Sale of securities on an exchange or to another person at price $ 88.00 per share. | 14 Oct 2020 | 220 | 23,370 (0%) | 0% | 88 | 19,360 | Common Stock |
| Mardi C. Dier | CFO & Executive Vice President | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Oct 2020 | 40,000 | 40,000 | - | - | Stock Option (Right to Buy) | |
| Mardi C. Dier | CFO & Executive Vice President | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Oct 2020 | 40,000 | 40,000 (0%) | 0% | 0 | Common Stock | |
| John Richard Pinion | See Remarks | Sale of securities on an exchange or to another person at price $ 94.47 per share. | 12 Oct 2020 | 2,780 | 46,561 (0%) | 0% | 94.5 | 262,627 | Common Stock |
| Karah Parschauer | EVP and General Counsel | Sale of securities on an exchange or to another person at price $ 95.00 per share. | 08 Oct 2020 | 10,000 | 24,293 (0%) | 0% | 95 | 950,000 | Common Stock |
| Karah Parschauer | EVP and General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Oct 2020 | 10,000 | 35,000 | - | - | Stock Option (Right to Buy) | |
| Karah Parschauer | EVP and General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 54.50 per share. | 08 Oct 2020 | 10,000 | 34,293 (0%) | 0% | 54.5 | 545,000 | Common Stock |
| Karah Parschauer | EVP and General Counsel | Sale of securities on an exchange or to another person at price $ 90.00 per share. | 06 Oct 2020 | 10,000 | 24,293 (0%) | 0% | 90 | 900,000 | Common Stock |
| Karah Parschauer | EVP and General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Oct 2020 | 10,000 | 17,000 | - | - | Stock Option (Right to Buy) | |
| Karah Parschauer | EVP and General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 48.43 per share. | 06 Oct 2020 | 10,000 | 34,293 (0%) | 0% | 48.4 | 484,300 | Common Stock |
| Karah Parschauer | EVP and General Counsel | Sale of securities on an exchange or to another person at price $ 85.00 per share. | 23 Sep 2020 | 10,000 | 24,293 (0%) | 0% | 85 | 850,000 | Common Stock |
| Karah Parschauer | EVP and General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 23 Sep 2020 | 10,000 | 27,000 | - | - | Stock Option (Right to Buy) | |
| Karah Parschauer | EVP and General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 48.43 per share. | 23 Sep 2020 | 10,000 | 34,293 (0%) | 0% | 48.4 | 484,300 | Common Stock |
| Emil D. Kakkis | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 82.63 per share. | 01 Sep 2020 | 30,000 | 2,389,741 (4%) | 0% | 82.6 | 2,478,900 | Common Stock |
| William E. Aliski | Director | Sale of securities on an exchange or to another person at price $ 86.57 per share. | 21 Aug 2020 | 5,000 | 57,018 (0%) | 0% | 86.6 | 432,850 | Common Stock |
| William E. Aliski | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Aug 2020 | 5,000 | 0 | - | - | Stock Option (Right to Buy) | |
| William E. Aliski | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 58.74 per share. | 21 Aug 2020 | 5,000 | 62,018 (0%) | 0% | 58.7 | 293,700 | Common Stock |
| Shalini Sharp | CFO & Executive Vice President | Sale of securities on an exchange or to another person at price $ 88.38 per share. | 17 Aug 2020 | 7,188 | 98,187 (0%) | 0% | 88.4 | 635,275 | Common Stock |
| Shalini Sharp | CFO & Executive Vice President | Sale of securities on an exchange or to another person at price $ 88.38 per share. | 17 Aug 2020 | 500 | 98,187 (0%) | 0% | 88.4 | 44,190 | Common Stock |
| Shalini Sharp | CFO & Executive Vice President | Exercise or conversion of derivative security received from the company (such as an option) at price $ 70.57 per share. | 17 Aug 2020 | 500 | 98,687 (0%) | 0% | 70.6 | 35,285 | Common Stock |
| Shalini Sharp | CFO & Executive Vice President | Sale of securities on an exchange or to another person at price $ 88.54 per share. | 17 Aug 2020 | 2,560 | 98,187 (0%) | 0% | 88.5 | 226,662 | Common Stock |
| Shalini Sharp | CFO & Executive Vice President | Sale of securities on an exchange or to another person at price $ 88.24 per share. | 17 Aug 2020 | 461 | 100,747 (0%) | 0% | 88.2 | 40,679 | Common Stock |
| Shalini Sharp | CFO & Executive Vice President | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Aug 2020 | 3,669 | 15,312 | - | - | Stock Option (Right to Buy) | |
| Shalini Sharp | CFO & Executive Vice President | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Aug 2020 | 7,188 | 15,812 | - | - | Stock Option (Right to Buy) | |
| Shalini Sharp | CFO & Executive Vice President | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Aug 2020 | 500 | 0 | - | - | Stock Option (Right to Buy) | |
| Shalini Sharp | CFO & Executive Vice President | Sale of securities on an exchange or to another person at price $ 88.38 per share. | 17 Aug 2020 | 3,669 | 98,187 (0%) | 0% | 88.4 | 324,266 | Common Stock |
| Shalini Sharp | CFO & Executive Vice President | Exercise or conversion of derivative security received from the company (such as an option) at price $ 48.43 per share. | 17 Aug 2020 | 3,669 | 101,856 (0%) | 0% | 48.4 | 177,690 | Common Stock |
| Shalini Sharp | CFO & Executive Vice President | Exercise or conversion of derivative security received from the company (such as an option) at price $ 67.55 per share. | 17 Aug 2020 | 7,188 | 105,375 (0%) | 0% | 67.5 | 485,549 | Common Stock |
| Karah Parschauer | EVP and General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Aug 2020 | 10,000 | 45,000 | - | - | Stock Option (Right to Buy) | |
| Karah Parschauer | EVP and General Counsel | Sale of securities on an exchange or to another person at price $ 88.39 per share. | 17 Aug 2020 | 2,370 | 24,293 (0%) | 0% | 88.4 | 209,484 | Common Stock |
| Karah Parschauer | EVP and General Counsel | Sale of securities on an exchange or to another person at price $ 88.44 per share. | 17 Aug 2020 | 10,000 | 26,663 (0%) | 0% | 88.4 | 884,400 | Common Stock |
| Karah Parschauer | EVP and General Counsel | Exercise or conversion of derivative security received from the company (such as an option) at price $ 54.50 per share. | 17 Aug 2020 | 10,000 | 36,663 (0%) | 0% | 54.5 | 545,000 | Common Stock |
| Clay B. Siegall | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 40.37 per share. | 07 Aug 2020 | 5,904 | 18,204 (0%) | 0% | 40.4 | 238,344 | Common Stock |
| Clay B. Siegall | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Aug 2020 | 1,596 | 0 | - | - | Stock Option (Right to Buy) | |
| Clay B. Siegall | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Aug 2020 | 17,500 | 0 | - | - | Stock Option (Right to Buy) | |
| Clay B. Siegall | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Aug 2020 | 5,904 | 1,596 | - | - | Stock Option (Right to Buy) | |
| Clay B. Siegall | Director | Sale of securities on an exchange or to another person at price $ 85.01 per share. | 07 Aug 2020 | 1,596 | 2,550 (0%) | 0% | 85.0 | 135,676 | Common Stock |
| Clay B. Siegall | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 40.37 per share. | 07 Aug 2020 | 1,596 | 4,146 (0%) | 0% | 40.4 | 64,431 | Common Stock |
| Clay B. Siegall | Director | Sale of securities on an exchange or to another person at price $ 85.01 per share. | 07 Aug 2020 | 9,750 | 2,550 (0%) | 0% | 85.0 | 828,848 | Common Stock |
| Clay B. Siegall | Director | Sale of securities on an exchange or to another person at price $ 85.55 per share. | 07 Aug 2020 | 23,404 | 12,300 (0%) | 0% | 85.5 | 2,002,212 | Common Stock |
| Clay B. Siegall | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 21.00 per share. | 07 Aug 2020 | 17,500 | 35,704 (0%) | 0% | 21 | 367,500 | Common Stock |
| Emil D. Kakkis | Director, President & CEO | Sale of securities on an exchange or to another person at price $ 85.35 per share. | 13 Jul 2020 | 40,000 | 2,419,741 (4%) | 0% | 85.4 | 3,414,000 | Common Stock |
| Theodore A. Huizenga | SVP, Controller and PAO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 21.00 per share. | 08 Jul 2020 | 2,000 | 18,582 (0%) | 0% | 21 | 42,000 | Common Stock |
| Theodore A. Huizenga | SVP, Controller and PAO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Jul 2020 | 2,000 | 12,000 | - | - | Stock Option (Right to Buy) | |
| Theodore A. Huizenga | SVP, Controller and PAO | Sale of securities on an exchange or to another person at price $ 91.00 per share. | 08 Jul 2020 | 2,000 | 16,582 (0%) | 0% | 91 | 182,000 | Common Stock |
| Theodore A. Huizenga | SVP, Controller and PAO | Sale of securities on an exchange or to another person at price $ 91.00 per share. | 08 Jul 2020 | 638 | 16,582 (0%) | 0% | 91 | 58,058 | Common Stock |
| Matthew K. Fust | Director | Sale of securities on an exchange or to another person at price $ 90.00 per share. | 06 Jul 2020 | 6,181 | 13,550 (0%) | 0% | 90 | 556,290 | Common Stock |
| Matthew K. Fust | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 21.00 per share. | 06 Jul 2020 | 6,181 | 19,731 (0%) | 0% | 21 | 129,801 | Common Stock |
| Matthew K. Fust | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Jul 2020 | 6,181 | 0 | - | - | Stock Option (Right to Buy) | |
| Erik Harris | EVP & Chief Commercial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 86.75 per share. | 06 Jul 2020 | 260 | 23,590 (0%) | 0% | 86.8 | 22,555 | Common Stock |
| Matthew K. Fust | Director | Sale of securities on an exchange or to another person at price $ 85.00 per share. | 01 Jul 2020 | 5,000 | 13,550 (0%) | 0% | 85 | 425,000 | Common Stock |
| Matthew K. Fust | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Jul 2020 | 5,000 | 6,181 | - | - | Stock Option (Right to Buy) | |
| Matthew K. Fust | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 21.00 per share. | 01 Jul 2020 | 5,000 | 18,550 (0%) | 0% | 21 | 105,000 | Common Stock |
| Theodore A. Huizenga | SVP, Controller and PAO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Jul 2020 | 1,500 | 14,000 | - | - | Stock Option (Right to Buy) | |
| Theodore A. Huizenga | SVP, Controller and PAO | Sale of securities on an exchange or to another person at price $ 81.00 per share. | 01 Jul 2020 | 1,500 | 17,220 (0%) | 0% | 81 | 121,500 | Common Stock |
| Theodore A. Huizenga | SVP, Controller and PAO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 21.00 per share. | 01 Jul 2020 | 1,500 | 18,720 (0%) | 0% | 21 | 31,500 | Common Stock |
| Theodore A. Huizenga | SVP, Controller and PAO | Sale of securities on an exchange or to another person at price $ 81.00 per share. | 01 Jul 2020 | 1,111 | 17,220 (0%) | 0% | 81 | 89,991 | Common Stock |
| Deborah L. Dunsire | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Jun 2020 | 2,550 | 10,425 (0%) | 0% | 0 | Common Stock | |
| Deborah L. Dunsire | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Jun 2020 | 4,250 | 4,250 | - | - | Stock Option (Right to Buy) | |
| Matthew K. Fust | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Jun 2020 | 2,550 | 13,550 (0%) | 0% | 0 | Common Stock | |
| Matthew K. Fust | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Jun 2020 | 4,250 | 4,250 | - | - | Stock Option (Right to Buy) | |
| Clay B. Siegall | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Jun 2020 | 2,550 | 12,300 (0%) | 0% | 0 | Common Stock | |
| Clay B. Siegall | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Jun 2020 | 4,250 | 4,250 | - | - | Stock Option (Right to Buy) | |
| Daniel G. Welch | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Jun 2020 | 4,250 | 4,250 | - | - | Stock Option (Right to Buy) | |
| Daniel G. Welch | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Jun 2020 | 2,550 | 12,300 (0%) | 0% | 0 | Common Stock | |
| Michael A. Narachi | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Jun 2020 | 4,250 | 4,250 | - | - | Stock Option (Right to Buy) | |
| Michael A. Narachi | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Jun 2020 | 2,550 | 12,300 (0%) | 0% | 0 | Common Stock | |
| Lars G. Ekman | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Jun 2020 | 4,250 | 4,250 | - | - | Stock Option (Right to Buy) | |
| Lars G. Ekman | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Jun 2020 | 2,550 | 12,300 (0%) | 0% | 0 | Common Stock | |
| William E. Aliski | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Jun 2020 | 2,550 | 57,018 (0%) | 0% | 0 | Common Stock | |
| William E. Aliski | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Jun 2020 | 4,250 | 4,250 | - | - | Stock Option (Right to Buy) | |
| Shehnaaz Suliman | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Jun 2020 | 2,550 | 5,550 (0%) | 0% | 0 | Common Stock | |
| Shehnaaz Suliman | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Jun 2020 | 4,250 | 4,250 | - | - | Stock Option (Right to Buy) | |
| Karah Parschauer | EVP and General Counsel | Payment of exercise price or tax liability using portion of securities received from the company at price $ 78.22 per share. | 20 Jun 2020 | 649 | 26,663 (0%) | 0% | 78.2 | 50,765 | Common Stock |
| Erik Harris | EVP & Chief Commercial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 78.22 per share. | 19 Jun 2020 | 303 | 23,850 (0%) | 0% | 78.2 | 23,701 | Common Stock |
| Shalini Sharp | CFO & Executive Vice President | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Jun 2020 | 2,564 | 18,981 | - | - | Stock Option (Right to Buy) | |
| Shalini Sharp | CFO & Executive Vice President | Exercise or conversion of derivative security received from the company (such as an option) at price $ 48.43 per share. | 03 Jun 2020 | 10,234 | 111,442 (0%) | 0% | 48.4 | 495,633 | Common Stock |
| Shalini Sharp | CFO & Executive Vice President | Sale of securities on an exchange or to another person at price $ 74.23 per share. | 03 Jun 2020 | 10,234 | 101,208 (0%) | 0% | 74.2 | 759,670 | Common Stock |
| Shalini Sharp | CFO & Executive Vice President | Exercise or conversion of derivative security received from the company (such as an option) at price $ 48.43 per share. | 03 Jun 2020 | 2,564 | 103,772 (0%) | 0% | 48.4 | 124,175 | Common Stock |
| Shalini Sharp | CFO & Executive Vice President | Sale of securities on an exchange or to another person at price $ 74.01 per share. | 03 Jun 2020 | 2,564 | 101,208 (0%) | 0% | 74.0 | 189,762 | Common Stock |
| Shalini Sharp | CFO & Executive Vice President | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Jun 2020 | 10,234 | 21,545 | - | - | Stock Option (Right to Buy) | |
| Shalini Sharp | CFO & Executive Vice President | Payment of exercise price or tax liability using portion of securities received from the company at price $ 69.38 per share. | 01 Jun 2020 | 348 | 101,208 (0%) | 0% | 69.4 | 24,144 | Common Stock |
| Emil D. Kakkis | Director, President & CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 69.38 per share. | 01 Jun 2020 | 1,334 | 611,041 (1%) | 0% | 69.4 | 92,553 | Common Stock |
| Thomas R. Kassberg | CBO & EVP | Payment of exercise price or tax liability using portion of securities received from the company at price $ 69.38 per share. | 01 Jun 2020 | 348 | 101,740 (0%) | 0% | 69.4 | 24,144 | Common Stock |
| Dennis Karl Huang | EVP & Chief Tech Ops Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 69.38 per share. | 01 Jun 2020 | 262 | 34,961 (0%) | 0% | 69.4 | 18,178 | Common Stock |
| John Richard Pinion | See Remarks | Payment of exercise price or tax liability using portion of securities received from the company at price $ 69.38 per share. | 01 Jun 2020 | 262 | 49,341 (0%) | 0% | 69.4 | 18,178 | Common Stock |
| Theodore A. Huizenga | SVP, Controller and PAO | Sale of securities on an exchange or to another person at price $ 74.93 per share. | 25 May 2020 | 260 | 18,331 (0%) | 0% | 74.9 | 19,482 | Common Stock |
| Theodore A. Huizenga | SVP, Controller and PAO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 73.81 per share. | 25 May 2020 | 433 | 18,591 (0%) | 0% | 73.8 | 31,960 | Common Stock |
| Matthew K. Fust | Director | Sale of securities on an exchange or to another person at price $ 75.00 per share. | 18 May 2020 | 1,875 | 11,000 (0%) | 0% | 75 | 140,625 | Common Stock |
| Shalini Sharp | CFO & Executive Vice President | Exercise or conversion of derivative security received from the company (such as an option) at price $ 48.43 per share. | 18 May 2020 | 3,221 | 104,165 (0%) | 0% | 48.4 | 155,993 | Common Stock |
| Shalini Sharp | CFO & Executive Vice President | Sale of securities on an exchange or to another person at price $ 73.32 per share. | 18 May 2020 | 3,221 | 100,944 (0%) | 0% | 73.3 | 236,164 | Common Stock |
| Shalini Sharp | CFO & Executive Vice President | Sale of securities on an exchange or to another person at price $ 73.29 per share. | 18 May 2020 | 2,392 | 100,944 (0%) | 0% | 73.3 | 175,310 | Common Stock |
| Shalini Sharp | CFO & Executive Vice President | Sale of securities on an exchange or to another person at price $ 73.34 per share. | 18 May 2020 | 19,593 | 103,336 (0%) | 0% | 73.3 | 1,436,951 | Common Stock |
| Shalini Sharp | CFO & Executive Vice President | Exercise or conversion of derivative security received from the company (such as an option) at price $ 70.57 per share. | 18 May 2020 | 19,593 | 122,929 (0%) | 0% | 70.6 | 1,382,678 | Common Stock |
| Shalini Sharp | CFO & Executive Vice President | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 May 2020 | 3,907 | 500 | - | - | Stock Option (Right to Buy) | |
| Shalini Sharp | CFO & Executive Vice President | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 May 2020 | 3,221 | 31,779 | - | - | Stock Option (Right to Buy) | |
| Shalini Sharp | CFO & Executive Vice President | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 May 2020 | 19,593 | 4,407 | - | - | Stock Option (Right to Buy) | |
| Shalini Sharp | CFO & Executive Vice President | Sale of securities on an exchange or to another person at price $ 73.32 per share. | 18 May 2020 | 3,907 | 101,556 (0%) | 0% | 73.3 | 286,461 | Common Stock |
| Shalini Sharp | CFO & Executive Vice President | Exercise or conversion of derivative security received from the company (such as an option) at price $ 70.57 per share. | 18 May 2020 | 3,907 | 104,851 (0%) | 0% | 70.6 | 275,717 | Common Stock |
| William E. Aliski | Director | Sale of securities on an exchange or to another person at price $ 74.02 per share. | 18 May 2020 | 20,000 | 70,350 (0%) | 0% | 74.0 | 1,480,322 | Common Stock |
| William E. Aliski | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 May 2020 | 7,500 | 0 | - | - | Stock Option (Right to Buy) | |
| William E. Aliski | Director | Sale of securities on an exchange or to another person at price $ 74.65 per share. | 18 May 2020 | 7,500 | 47,924 (0%) | 0% | 74.7 | 559,875 | Common Stock |
| William E. Aliski | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 40.37 per share. | 18 May 2020 | 7,500 | 55,424 (0%) | 0% | 40.4 | 302,775 | Common Stock |
| Karah Parschauer | EVP and General Counsel | Sale of securities on an exchange or to another person at price $ 74.71 per share. | 18 May 2020 | 2,722 | 27,312 (0%) | 0% | 74.7 | 203,374 | Common Stock |
| Theodore A. Huizenga | SVP, Controller and PAO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 May 2020 | 1,500 | 15,500 | - | - | Stock Option (Right to Buy) | |
| Theodore A. Huizenga | SVP, Controller and PAO | Sale of securities on an exchange or to another person at price $ 71.00 per share. | 15 May 2020 | 1,500 | 19,024 (0%) | 0% | 71 | 106,500 | Common Stock |
| Theodore A. Huizenga | SVP, Controller and PAO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 21.00 per share. | 15 May 2020 | 1,500 | 20,219 (0%) | 0% | 21 | 31,500 | Common Stock |
| Theodore A. Huizenga | SVP, Controller and PAO | Sale of securities on an exchange or to another person at price $ 71.00 per share. | 15 May 2020 | 961 | 18,719 (0%) | 0% | 71 | 68,231 | Common Stock |
| Shalini Sharp | CFO & Executive Vice President | Payment of exercise price or tax liability using portion of securities received from the company at price $ 66.26 per share. | 06 May 2020 | 248 | 103,336 (0%) | 0% | 66.3 | 16,432 | Common Stock |
| Emil D. Kakkis | Director, President & CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 66.26 per share. | 06 May 2020 | 852 | 652,797 (1%) | 0% | 66.3 | 56,454 | Common Stock |
| Thomas R. Kassberg | CBO & EVP | Payment of exercise price or tax liability using portion of securities received from the company at price $ 66.26 per share. | 06 May 2020 | 248 | 101,675 (0%) | 0% | 66.3 | 16,432 | Common Stock |
| Camille L. Bedrosian | EVP and Chief Medical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 66.26 per share. | 06 May 2020 | 249 | 36,051 (0%) | 0% | 66.3 | 16,499 | Common Stock |
| Theodore A. Huizenga | SVP, Controller and PAO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 66.26 per share. | 06 May 2020 | 138 | 19,680 (0%) | 0% | 66.3 | 9,144 | Common Stock |
| Karah Parschauer | EVP and General Counsel | Payment of exercise price or tax liability using portion of securities received from the company at price $ 66.26 per share. | 06 May 2020 | 248 | 29,904 (0%) | 0% | 66.3 | 16,432 | Common Stock |
| Dennis Karl Huang | EVP & Chief Tech Ops Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 66.26 per share. | 06 May 2020 | 248 | 34,979 (0%) | 0% | 66.3 | 16,432 | Common Stock |
| John Richard Pinion | See Remarks | Payment of exercise price or tax liability using portion of securities received from the company at price $ 66.26 per share. | 06 May 2020 | 248 | 48,991 (0%) | 0% | 66.3 | 16,432 | Common Stock |
| Erik Harris | EVP & Chief Commercial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 66.26 per share. | 06 May 2020 | 209 | 24,153 (0%) | 0% | 66.3 | 13,848 | Common Stock |
| Matthew K. Fust | Director | Sale of securities on an exchange or to another person at price $ 65.00 per share. | 22 Apr 2020 | 1,875 | 12,875 (0%) | 0% | 65 | 121,875 | Common Stock |
| Shalini Sharp | CFO & Executive Vice President | Payment of exercise price or tax liability using portion of securities received from the company at price $ 58.57 per share. | 19 Apr 2020 | 248 | 103,584 (0%) | 0% | 58.6 | 14,525 | Common Stock |
| Emil D. Kakkis | Director, President & CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 58.57 per share. | 19 Apr 2020 | 851 | 653,649 (1%) | 0% | 58.6 | 49,843 | Common Stock |
| Thomas R. Kassberg | CBO & EVP | Payment of exercise price or tax liability using portion of securities received from the company at price $ 58.57 per share. | 19 Apr 2020 | 248 | 101,923 (0%) | 0% | 58.6 | 14,525 | Common Stock |
| Theodore A. Huizenga | SVP, Controller and PAO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 58.57 per share. | 19 Apr 2020 | 140 | 19,818 (0%) | 0% | 58.6 | 8,200 | Common Stock |
| Karah Parschauer | EVP and General Counsel | Payment of exercise price or tax liability using portion of securities received from the company at price $ 58.57 per share. | 19 Apr 2020 | 248 | 30,152 (0%) | 0% | 58.6 | 14,525 | Common Stock |
| Dennis Karl Huang | EVP & Chief Tech Ops Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 58.57 per share. | 19 Apr 2020 | 248 | 35,227 (0%) | 0% | 58.6 | 14,525 | Common Stock |
| John Richard Pinion | See Remarks | Payment of exercise price or tax liability using portion of securities received from the company at price $ 58.57 per share. | 19 Apr 2020 | 248 | 49,239 (0%) | 0% | 58.6 | 14,525 | Common Stock |
| Erik Harris | EVP & Chief Commercial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 58.57 per share. | 19 Apr 2020 | 210 | 24,362 (0%) | 0% | 58.6 | 12,300 | Common Stock |
| Emil D. Kakkis | Director, President & CEO | 12 Mar 2020 | 66,533 | 0 | - | - | Warrant (Right to Buy) | ||
| Emil D. Kakkis | Director, President & CEO | 12 Mar 2020 | 66,533 | 654,500 (1%) | 0% | 3.0 | 199,998 | Common Stock | |
| Emil D. Kakkis | Director, President & CEO | 12 Mar 2020 | 83,167 | 587,967 (1%) | 0% | 3.0 | 250,000 | Common Stock | |
| Emil D. Kakkis | Director, President & CEO | 12 Mar 2020 | 83,167 | 0 | - | - | Warrant (Right to Buy) | ||
| Shalini Sharp | CFO & Executive Vice President | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2020 | 5,634 | 106,157 (0%) | 0% | 0 | Common Stock | |
| Shalini Sharp | CFO & Executive Vice President | Payment of exercise price or tax liability using portion of securities received from the company at price $ 56.08 per share. | 01 Mar 2020 | 2,325 | 103,832 (0%) | 0% | 56.1 | 130,386 | Common Stock |
| Emil D. Kakkis | Director, President & CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 56.08 per share. | 01 Mar 2020 | 6,896 | 504,800 (0%) | 0% | 56.1 | 386,728 | Common Stock |
| Emil D. Kakkis | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2020 | 18,782 | 511,696 (0%) | 0% | 0 | Common Stock | |
| Emil D. Kakkis | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2020 | 17,000 | 492,914 (0%) | 0% | 0 | Common Stock | |
| Emil D. Kakkis | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2020 | 56,100 | 56,100 | - | - | Stock Option (Right to Buy) | |
| Thomas R. Kassberg | CBO & EVP | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2020 | 5,634 | 104,109 (0%) | 0% | 0 | Common Stock | |
| Thomas R. Kassberg | CBO & EVP | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2020 | 6,800 | 98,475 (0%) | 0% | 0 | Common Stock | |
| Thomas R. Kassberg | CBO & EVP | Payment of exercise price or tax liability using portion of securities received from the company at price $ 56.08 per share. | 01 Mar 2020 | 2,067 | 102,171 (0%) | 0% | 56.1 | 115,917 | Common Stock |
| Thomas R. Kassberg | CBO & EVP | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2020 | 20,000 | 20,000 | - | - | Stock Option (Right to Buy) | |
| Camille L. Bedrosian | EVP and Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2020 | 21,000 | 21,000 | - | - | Stock Option (Right to Buy) | |
| Camille L. Bedrosian | EVP and Chief Medical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 56.08 per share. | 01 Mar 2020 | 1,249 | 36,300 (0%) | 0% | 56.1 | 70,044 | Common Stock |
| Camille L. Bedrosian | EVP and Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2020 | 7,300 | 31,915 (0%) | 0% | 0 | Common Stock | |
| Camille L. Bedrosian | EVP and Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2020 | 5,634 | 37,549 (0%) | 0% | 0 | Common Stock | |
| Theodore A. Huizenga | SVP, Controller and PAO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2020 | 4,400 | 19,958 (0%) | 0% | 0 | Common Stock | |
| Theodore A. Huizenga | SVP, Controller and PAO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2020 | 13,280 | 13,280 | - | - | Stock Option (Right to Buy) | |
| Karah Parschauer | EVP and General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2020 | 22,000 | 22,000 | - | - | Stock Option (Right to Buy) | |
| Karah Parschauer | EVP and General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2020 | 5,634 | 32,518 (0%) | 0% | 0 | Common Stock | |
| Karah Parschauer | EVP and General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Mar 2020 | 7,800 | 26,884 (0%) | 0% | 0 | Common Stock | |
| Karah Parschauer | EVP and General Counsel | Payment of exercise price or tax liability using portion of securities received from the company at price $ 56.08 per share. | 01 Mar 2020 | 2,118 | 30,400 (0%) | 0% | 56.1 | 118,777 | Common Stock |